General Information

  • ID:  hor005603
  • Uniprot ID:  Q801Y3
  • Protein name:  Hepcidin-1
  • Gene name:  hamp1
  • Organism:  Salmo salar (Atlantic salmon)
  • Family:  Hepcidin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Salmo (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006879 intracellular iron ion homeostasis; GO:0007165 signal transduction; GO:0042742 defense response to bacterium
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QIHLSLCGLCCNCCHNIGCGFCCKF
  • Length:  25(62-86)
  • Propeptide:  MKAFSVAVVLVIACMFILESTAVPFSEVRTEEVGSFDSPVGEHQQPGGESMHLPEPFRFKRQIHLSLCGLCCNCCHNIGCGFCCKF
  • Signal peptide:  MKAFSVAVVLVIACMFILESTA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  7-23; 10-13; 11-19; 14-22
  • Structure ID:  AF-P51924-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005603_AF2.pdbhor005603_ESM.pdb

Physical Information

Mass: 314862 Formula: C112H175N33O30S8
Absent amino acids: ADEMPRTVWY Common amino acids: C
pI: 7.67 Basic residues: 3
Polar residues: 14 Hydrophobic residues: 7
Hydrophobicity: 92.8 Boman Index: 653
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 5347.2 Extinction Coefficient cystines: 500
Absorbance 280nm: 20.83

Literature

  • PubMed ID:  12697315
  • Title:  Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish.